Fig. 3.

IKK2 inhibition disrupts HUVEC cytoskeleton, filopodia structure development and cell-to-cell interaction. a Impact of IMD0354 on HUVEC cytoskeleton arrangement examined by phalloidin staining (red), Actin-F aggregates in the cytoplasm of HUVEC is indicated by arrows. Cell nuclei visualized with DAPI staining (blue). b Scanning electron microscopy (SEM) images of HUVEC surface and cellular filopodia when treated with IMD0354 (10, 5, 2.5 ng/ml). c Enlarged SEM images indicate changes in cell-to-cell filopodia interactions with IMD0354 treatment