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. 2018 Feb 21;596(7):1259–1276. doi: 10.1113/JP275147

Figure 5. Both Shank3 Δ13–16 and HCN2 knockout neurons show hyperpolarizing shift in resting membrane potential and increase in input resistance, in contrast to Shank3 Δ4–9 neurons.

Figure 5

A, VB neurons from both heterozygous and homozygous Shank3 Δ13–16 mice show significantly more negative RMP (left) and increased R in (right). WT, n = 9; Shank3 Δ13–16+/−, n = 11; Shank3 Δ13–16−/−, n = 12. B, VB neurons from HCN2 heterozygous and homozygous mice show almost the same trend of changes compared to Shank3 Δ13–16 neurons. Left, RMP; right, R in. WT, n = 8; HCN2+/−, n = 8; HCN2−/−, n = 7. C, the RMP (left) and R in (right) of VB neurons from Shank3 Δ4–9 heterozygous and homozygous mice remained largely normal. All results were collected at room temperature. WT, n = 6; Shank3 Δ4–9+/−, n = 13; Shank3 Δ4–9−/−, n = 9. All n.s. D, the RMP (left), R in (middle), and the membrane capacitance (right) of VB neurons from Shank3 Δ4–9 homozygous mice remained largely normal compared to WT mice. Results were collected at 32°C. All n.s. WT, n = 9; Shank3 Δ4–9−/−, n = 8.