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Experimental timeline for nanoformulated drug treatment and blood and tissue collection. NanoATV/r or nanoATV were administered on days 0, 3, 7, 14, and 21 by intramuscular injection to hCYP3A-NOG and NOG mice. Whole blood was collected into heparinized tubes on days 1, 3, 7, 14, 21, and 28 and plasma was prepared. Liver tissue was collected at day 28.
