TABLE 1.
AUC for plasma ATV and RTV
Data are expressed as average (ng d/ml) ± S.E.M. Significantly different from NOG mice value: *P < 0.05; ****P < 0.0001. Significantly different from 50 mg/kg nanoATV/r treated mice of similar strain: †P < 0.05; ††P < 0.001.
| Strain and Treatment |
N |
ATV |
RTV |
|---|---|---|---|
| ng d/ml | ng d/ml | ||
| hCYP3A-NOG mice, 20 mg/kg nanoATV/r | |||
| All | 8 | 4891 ± 663* | 868 ± 229 |
| Male | 5 | 4498 ± 686 | 663 ± 77 |
| Female | 3 | 5548 ± 730 | 1209 ± 306 |
| hCYP3A-NOG mice, 50 mg/kg nanoATV/r | |||
| All | 7 | 19,430 ± 2058**** | 3687 ± 439 |
| Male | 4 | 16,729 ± 1309 | 3023 ± 463 |
| Female | 3 | 23,031 ± 2110a | 4457 ± 584 |
| hCYP3A-NOG mice, 50 mg/kg nanoATV | |||
| All | 5 | 7111 ± 717†† | |
| NOG mice, 20 mg/kg nanoATV/r | |||
| All | 8 | 2621 ± 781 | 1674 ± 863 |
| Male | 5 | 2201 ± 234 | 1778 ± 1088 |
| Female | 3 | 3322 ± 1237 | 1498 ± 453 |
| NOG mice, 50 mg/kg nanoATV/r | |||
| All | 7 | 4590 ± 516 | 2087 ± 217 |
| Male | 4 | 4101 ± 198 | 2056 ± 339 |
| Female | 3 | 5242 ± 654 | 2130 ± 300 |
| NOG mice, 50 mg/kg nanoATV | |||
| All | 5 | 2402 ± 486† |
a
Significantly different from nanoATV/r male mice of similar strain and treatment (P < 0.05).