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Total plasma (solid line with square) concentration and brain (dashed line with circle) concentration in wild-type mice (A) and Mdr1a/b(−/−)Bcrp1(−/−) mice (B), and brain-to-plasma ratio time course of ponatinib after administration of a single intravenous bolus (3 mg/kg) in FVB wild-type and Mdr1a/b(−/−)Bcrp1(−/−) mice (N = 3 to 4 at each time point) (C). Data are presented as the mean ± S.D.
