Fig. 3.

Total plasma (solid line with square) and brain (dashed line with circle) concentration-time profiles after administration of a single oral dose (30 mg/kg) of ponatinib in FVB wild-type (A), Bcrp1(−/−) (B), Mdr1a/b(−/−) (C), and Mdr1a/b(−/−)Bcrp1(−/) (D) mice (N = 4 at each time point). Data are presented as mean ± S.D. Data for the wild-type mice were previously reported (Laramy et al., 2017) and included in this present study to compare the wild-type genotype with the three other genotypes that lack efflux transporters.