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Total brain-to-plasma ratio profiles after administration of a single oral dose (30 mg/kg) in FVB wild-type, Bcrp1(−/−), Mdr1a/b(−/−), and Mdr1a/b(−/−)Bcrp1(−/−) mice (N = 4 at each time point). Data are presented as the mean ± S.D. Data for the wild-type were previously reported (Laramy et al., 2017) and were included in this present study to compare the wild-type genotype with the three other genotypes that lack efflux transporters.
