TABLE 5.
Pharmacokinetic parameters obtained from an open two-compartment model that described the total plasma concentration-time profiles from naive-pooled analysis of all genotypes (N = 4 at each time point) after a single intravenous bolus (3 mg/kg) or oral dose (30 mg/kg)
The parameters are presented as the mean estimate.
| Mean | CV% | 95% Confidence Interval | |
|---|---|---|---|
| Estimated parameters | |||
| Vcentral (ml/kg) | 1478.3 | 8.1 | (964.8, 1991.9) |
| K10 (h−1) | 0.47 | 6.4 | (0.34, 0.60) |
| K21 (h−1) | 2.34 | 19.2 | (0.41, 4.3) |
| K12 (h−1) | 2.15 | 10.4 | (1.2, 3.1) |
| Kelim (h−1) | 0.21 | 1.7 | (0.20, 0.23) |
| Ka (h−1) | 0.28 | 11.5 | (0.20, 0.36) |
| Calculated parameters | |||
| Vu,central (l/kg) | 645.8 | ||
| CLsystemic (ml/min per kilogram) | 5.2 | 1.7 | (4.8, 5.6) |
| Half-life (h)a | 3.3 | 1.7 | (3.0, 3.5) |
a
Half-life of ponatinib (total drug) from the systemic circulation (body).