. 2018 May;365(2):249–261. doi: 10.1124/jpet.117.246116

TABLE 6.

Pharmacokinetic parameters obtained from the compartmental BBB model describing the brain and plasma concentration-time after administration of a single intravenous bolus (3 mg/kg, i.v.; N = 3 to 4 at each time point) or oral dose (30 mg/kg, PO; N = 4 at each time point) in FVB wild-type, Bcrp1(−/−), Mdr1a/b(−/−), and/or Mdr1a/b(−/−)Bcrp1(−/−) mice

Fixed values are left as blank (—). The parameters are presented as the mean estimate.

Route of Administration	Genotype	Parameters
		k_in (h⁻¹)		k_out (h⁻¹)		MTT_brain (h)^a	CL_in (ml/h per kilogram)		CL_out (ml/h per kilogram)		CL_u,in (ml/h per kilogram)		CL_u,out (ml/h per kilogram)
		Mean	CV (%)	Mean	CV (%)	Mean	Mean	CV (%)	Mean	CV (%)	Mean	CV (%)	Mean	CV (%)
Intravenous	WT	4.0 × 10⁻⁵	—	7.7	10.2	0.13	0.059	—	0.066	36.6	25.8	—	225.8	22.5
	TKO	4.0 × 10⁻⁵	11.2	0.64	14.0	1.6	0.059	13.8	0.0055	37.9	25.8	11.2	18.7	24.4
By mouth	WT	5.5 × 10⁻⁵	—	12.4	2.7	0.081	0.081	—	0.11	35.3	35.2	—	361.6	20.2
	Bcrp-KO	5.5 × 10⁻⁵	—	8.2	18.2	0.12	0.081	—	0.070	39.6	35.2	—	239.4	27.0
	Pgp-KO	5.5 × 10⁻⁵	—	2.9	26.0	0.34	0.081	—	0.025	43.8	35.2	—	85.1	32.8
	TKO	5.5 × 10⁻⁵	16.2	0.65	15.7	1.5	0.081	18.1	0.0056	38.5	35.2	16.2	19.0	25.5

Bcrp-KO, Bcrp1(−/−); KO, knockout; Pgp-KO, Mdr1a/b(−/−); TKO, Mdr1a/b(−/−)Bcrp1(−/−); WT, wild-type.

^{^a}

Calculated by 1/k_out.