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. Author manuscript; available in PMC: 2019 Mar 27.
Published in final edited form as: ACS Nano. 2018 Mar 1;12(3):2106–2121. doi: 10.1021/acsnano.7b07252

Figure 2.

Figure 2

Multimodality and “smart” NP imaging platforms. (A) Gadolinium NPs self-assemble in the presence of caspase 3/7 enzymes (“treated” group), increasing MRI contrast. Reproduced with permission from ref 79. Copyright 2014 The Royal Society of Chemistry. (B) Gadolinium–gold nanoshells provide contrast in both MRI (left) and X-ray (right) imaging. Reproduced with permission from ref 22. Copyright 2014 John Wiley & Sons. (C) SPIONs labeled with *As allow PET and MRI-based sentinel lymph node mapping. Reproduced with permission from ref 69. Copyright 2013 John Wiley & Sons. (D) NPs disassemble in the presence of GSH in the tumor, activating fluorescence. MRI also shows the presence of the NPs. Reprinted from ref 77. Copyright 2016 American Chemical Society. (E) Liposomes loaded with NIR dyes and 64Cu enable fluorescent and PET imaging of an orthotopic brain tumor. Reprinted from ref 70. Copyright 2012 American Chemical Society.