Fig. 4.

Increased mtDNA copy number promoted metastasis of MSS CRC cells. a, b Representative images of the wound-healing assay in SW480 and Caco-2 cells with treatment as indicated. c, d Transwell invasion analysis for CRC cells with treatment as indicated. e H&E staining of the lungs from tail-vein-injected mice (left). Quantification of lung metastases (right). The data shown are the mean ± SEM from three separate experiments. *P < 0.05; **P < 0.01