Table 5.

Pro-convulsant properties of nutritional magnesium deficiency and their modulation under various diet designs.

	Diet design and magnesium content
	NM commercial diet	NM MUFA diet	MD n-6PUFA diet	MD MUFA diet	MD n-3PUFA diet
MES test (current amperage needed to induce seizures in 33% of mice) (mA)	7	7	4	4	4.5
Ptz seizure test (LD100) (mg/kg)	85	87	55	57	57
NMDA seizure test (LD100) (mg/kg)	137	135	51	52	58
MDDAS test
Percentage of convulsing mice (%)	0	0	100	100	50
Percentage of deaths (%)	0	0	50	50	0

Note: Results are means of seizure test condition parameters including percentage of convulsing mice and of animal deaths, and dose of the chemical (Ptz, pentylenetetrazole, NMDA, N-methyl-D-aspartate) needed to induce lethal seizures in 100% of tested mice (LD100, lethal dose 100). NM and MD indicate normal and deficient magnesium contents of the diets, respectively. Data collected for other NM diet conditions did not distinguish from those appearing in this Table. Abbreviations are MES, maximal electroshock-induced seizures; MDDAS, magnesium deficiency-dependent audiogenic seizures.