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Possible involvement of tumor necrosis factor- (TNF-) α in the reactivation of cytomegalovirus (CMV) and human herpesvirus (HHV)-6. TNF-α may play a role in reactivation of Betaherpesvirinae subfamily members, including CMV and HHV-6. TNF-α enhances the expression of CMV immediate early gene products. Enhancement of HHV-6 U95 gene expression by the R3 region of HHV-6 might interact with nuclear factor- (NF-) κB by TNF-α.
