Figure 1.

Andrographolide (Andro) improved CCl₄-induced liver fibrosis in mice. (a) Representative histology of Sirius Red and immunohistochemical staining of α-SMA and TGF-β1. (b–d) Quantification of positive staining areas was measured by ImageJ software. (e) Hepatic hydroxyproline content. (f) The protein expression of α-SMA and TGF-β1 was examined by Western blot. (g, h) Serum levels of ALT and AST. n = 6. ^### p < 0.001 versus control mice. ^∗ p < 0.05 and ^∗∗ p < 0.01 versus mice induced by CCl₄.