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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Heart Rhythm. 2017 Dec 14;15(4):578–586. doi: 10.1016/j.hrthm.2017.12.017

Figure 2.

Figure 2

EL20 inhibition of abnormal Ca2+ release events at the cellular level. (A) Summary data showing EL20 (500nM) reduced CaSF in R176Q (grey bars) ventricular myocytes compared to vehicle (and little effect on WT (white bars) myocytes). (B) Summary data showing that EL20 (500nM) did not alter the Ca2+ transient amplitude in both WT and R176Q ventricular myocytes. (C) Dose-response relationship and IC50 determination of EL20 using CaSF inhibition in R176Q myocytes (n=6–10 cells per group, 3 mice). Results summarized in Table 1. Data presented as mean ± SEM (*P<0.05, **P<0.01).