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. 2018 Mar 26;6:29. doi: 10.3389/fcell.2018.00029

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Copyright © 2018 Jackson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Arf1 G protein is activated by guanine nucleotide exchange factors (GEFs) through their catalysis of GDP nucleotide release from Arf. Binding of the more abundant GTP in cells leads to conformational changes in the small G protein, allowing it to interact with numerous proteins called effectors. The major classes of Arf1 effectors are listed, and a few examples of each are indicated in parentheses. COPI, coat protein complex I; AP, adaptor protein; PI4 kinase, phosphatidylinositol-4-kinae; OSBP, oxysterol binding protein; CERT, ceramide transfer protein.