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. 2018 Mar 26;9:558. doi: 10.3389/fimmu.2018.00558

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Copyright © 2018 Hair, Enos, Krishna and Cunnion.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PA-dPEG24 inhibition of heat-aggregated IgG (Agg-IgG) immune complex-initated complement activation assayed by complement effectors. (A) PA-dPEG24 inhibition of C5a generation in normal human sera (NHS) stimulated with heat-Agg-IgG immune complexes (IC). Data are means of (n = 5) independent experiments ± SEM. (B) PA-dPEG24 inhibition of iC3b generation in NHS stimulated with heat-Agg-IgG IC. Data are means of (n = 4) independent experiments ± SEM. (C) PA-dPEG24 inhibition of SC5b-9 generation in NHS stimulated with heat-Agg-IgG IC. Data are means of (n = 6) independent experiments ± SEM.