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. 2018 Mar 26;9:255. doi: 10.3389/fphar.2018.00255

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Copyright © 2018 Zhou, Lankhuizen, van Beusekom, Cheng, Duncker and Merkus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P1 receptor blockade with 8PT attenuated relaxation to Up₄A less in coronary small arteries from Sham-operated swine (A, n = 6) as compared to coronary small arteries from swine with AoB (B, n = 6). A_2A receptor blockade with SCH58261 attenuated Up₄A-induced relaxation in coronary small arteries from Sham (n = 5), but not AoB (n = 5). Control data are the same as in Figure 2 (‘Sham’ and ‘AoB’). ^∗P < 0.05 effect of 8PT vs. corresponding control. ^†P < 0.05 effect of 8PT vs. corresponding SCH58261.