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. 2018 Mar 26;9:255. doi: 10.3389/fphar.2018.00255

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Copyright © 2018 Zhou, Lankhuizen, van Beusekom, Cheng, Duncker and Merkus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P2X₁ receptor blockade with MRS2159 attenuated relaxation to Up₄A to the same extent in coronary small arteries from Sham-operated swine (A, n = 8) and from swine with AoB (B, n = 6), whereas and P2Y₁ receptor blockade with MRS2179 attenuated relaxation to Up₄A in coronary small arteries from Sham-operated swine (C, n = 7) but not from swine with AoB (D, n = 5). Control data are the same as in Figure 2 (‘Sham’ and ‘AoB’).^∗P < 0.05 effect of MRS2159 or MRS2179 vs. corresponding control.