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. 2018 Mar 26;9:255. doi: 10.3389/fphar.2018.00255

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Copyright © 2018 Zhou, Lankhuizen, van Beusekom, Cheng, Duncker and Merkus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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eNOS inhibition with LNAME attenuated the response to Up₄A to a similar extent in coronary small arteries from Sham-operated swine (A, n = 8) and swine with AoB (B, n = 7). Subsequent inhibition of cyclooxygenase with indomethacin (Indo) had no effect in vessels from Sham (C, n = 7), but enhanced relaxation to Up₄A in vessels from swine with AoB (D, n = 6). Control data are the same as in Figure 2 (‘Sham’ and ‘AoB’). ^∗P < 0.05 effect of LNAME vs. corresponding control; ^†P < 0.05 effect of LNAME + indomethacin vs. LNAME alone.