FIGURE 9.

Neither TxS inhibition with ozagrel, nor P2Y₁₂ receptor blockade with clopidogrel (Clop), nor the combination affected the response to Up₄A in coronary small arteries from slaughterhouse swine with intact endothelium (A, n = 5). Ozagrel and clopidogrel enhanced vasodilator response to Up₄A in denuded coronary small arteries, while the effect of the combination of ozagrel and clopidogrel was similar to the effect of either inhibitor alone (B, n = 5). Control data are the same as in Figure 2 ‘Slaughterhouse.’ ^∗P < 0.05 effect of denudation; †P < 0.05 effect of ozagrel and/or clopidogrel vs. corresponding control.