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. 2018 Mar 26;9:274. doi: 10.3389/fphar.2018.00274

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Copyright © 2018 Feng, Huang, Guo, Liang, Xiang, Lei, Shi, Li, Liu, Feng, Ma and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of HDAC6 with 23BB alleviates glycerol-induced AKI. (A) Serum creatinine (sCr). (B) Serum blood urea nitrogen (BUN). (C) Serum creatine kinase (CK). (D) Photomicrographs (X400) illustrate periodic acid-Schiff (PAS) staining of the kidney tissues (red triangle: tubular dilatation; red arrow: necrosis; yellow triangle: cast formation; yellow arrow: loss of brush border). Histologic changes were scored based on the scale described in the Section “Materials and Methods.” Data are represented as the means ± SE (n = 6 for each group). ^∗∗∗∗P < 0.0001; ^∗P < 0.05.