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. 2018 Mar 26;8:208. doi: 10.3389/fgene.2017.00208

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Copyright © 2018 Tano, Onoguchi-Mizutani, Yeasmin, Uchiumi, Suzuki, Yada and Akimitsu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of the MALAT1-responsive region in the human p53 promoter. (A) The activities of the human p53 promoter regions (pGL2-356,−200, and −100 bp) in MALAT1-knockdown cells were examined using luciferase assays. The data are presented as fold induction compared with the activity in control cells. The p53 promoter-reporter firefly luciferase activity is indicated relative to the activity of the Renilla luciferase control. All transfections were normalized with equal amounts of pGL2-Control vector. Data are means ± SD (n = 3 each, ^**P < 0.01, ^***P < 0.001, Student's t-test). (B) The relative luciferase activities of the 5′ deletion mutant promoters in MALAT1-knockdown cells compared with control cells were determined. Data is shown as fold induction compared with the activity in the control cells (activity in the control cells was set at 1.0).