FIG 7.
Mafb deletion impairs glucagon secretion upon α-cell stimulation. (A and B) Glucagon secretion was measured after intraperitoneal injection of l-arginine (1 mg/g) in 8-week-old MafbΔEndo (n ≥ 8) (A) and MafbΔTAM (B) male mice (n ≥ 4) 3 weeks post-TAM administration. TAM was injected at 5 weeks of age. **, P < 0.01. (C and D) qPCR analysis of glucagon secretion machinery gene expression was performed on pancreatic islets isolated from 10-week-old MafbΔEndo (C) and MafbΔTAM (D) mice (n ≥ 5) 3 weeks post-TAM injection. *, P < 0.05; **, P < 0.01. Means and SEM are shown.