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. 2018 Feb 7;4(3):387–396. doi: 10.1021/acscentsci.7b00589

Figure 4.

Figure 4

(A) Structures of deuterated arachidonic acids. HPETE formation in cells overexpressing 5-LOX (B), p12-LOX (C), and 15-LOX-1 (D) incubated with 70 μM AA (black), 7,7,10,10,13,13-d6-AA (red), 7,7-d2-AA (blue), 10,10-d2-AA (green), and 13,13-d2-AA (magenta). RSL3-induced ferroptosis in nontransfected HEK293 cells (E) and transfected cells overexpressing 5-LOX (F), p12-LOX (G), and 15-LOX-1 (H) preincubated with 40 μM arachidonic acid (black, ●), 7,7-d2-AA (blue, ▲), 10,10-d2-AA (green, ◆), 13,13-d2-AA (magenta, ▼), and 7,7,10,10,13,13-d6-AA (red, ■).