Table 2.

PERV inoculation experiments into small animals and NHP

Recipient	Virus source	Immuno-suppression, treatment	PERV testing		References
			PCR analysis	Antibody detection
SCID micea	Human cell-adapted PERV	None	Negative	nt	Irgang et al. [45]
	Transplantation of pig PBMCs	None	Negative	nt	Kuddus et al. [72]
Rats	Supernatant PK-15 cells, supernatant PERV-infected 293 cells, human cell-adapted PERV	Cyclosporine A, cobra venom factor	Negative	Negative	Denner et al. [73]
Mink	Supernatant PERV-infected 293 cells, human cell-adapted PERV	None	Negative	Negative	Specke et al. [39]
Guinea pigs	Supernatant PK-15 cells, supernatant PERV-infected 293 cells	None	Negative	Negative	Specke et al. [44]
	PERV-NIH	None	Transient positive	Positive	Argaw et al. [71]
Rhesus monkeys, pig-tailed monkeys, baboons	Human cell-adapted PERV	Cyclosporine A, everolimus (RAD), methyl-prednisolone	Negative	Negative	Specke et al. [41, 42]

Nt not tested

^aReports showing that SCID mice were infected with PERV [74, 75] were the result of an artefact based on pseudotyping between PERV and endogenous murine retroviruses [76, 77]