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. 2018 Apr 2;37:73. doi: 10.1186/s13046-018-0743-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Downregulation of SGK1 inhibits metastasis in vivo. Briefly, 2 × 10⁶ PC3^LV2-Ctrl cells or 2 × 10⁶ PC3^shSGK1 cells suspended in 0.2 ml PBS were inoculated subcutaneously in the right flank of each mouse. When the tumors of the PC3^LV2 group reached approximately 500 mm³, all mice were sacrifice to collect the tumors. a SGK1, LC3B, Fibronectin (FN1) and MMP3 levels were determined by IHC. Representative images are presented. b Mean optical density of SGK1, LC3B, Fibronectin (FN1) and MMP3 was quantified by Image Pro-Plus. c The levels of SGK1, LC3B, E-cad, N-cad, Vimentin and MMP9 in tumor xenograft tissues were also detected by western blot. *P < 0.05