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PPK2 catalysis and substrate binding. (A) Phosphotransfer reactions catalyzed by PPK2 classes. R, nucleobase. (B) PolyP binding to FtPPK2. The lid loop is shown in yellow and the Walker A motif (P-loop) is shown in blue. P9, nonaphosphate. (C) Active-site region of the FtPPK2:AMPPCPPP:polyP complex. The lid loop is shown in yellow. Ad, adenine moiety; P6, hexaphosphate; W, water.
