Table 2.
Results of one-way ANOVA analysis conducted for each ERG stimulus condition
| ERG amplitude | WT | rd10 NT | rd10 + LP | rd10 + LP-CN03 | df | F | P | ||||||||
| n | Mean, μV | SD, μV | n | Mean, μV | SD, μV | n | Mean, μV | SD, μV | n | Mean, μV | SD, μV | ||||
| Scotopic single flash 0.0001 | |||||||||||||||
| b-wave | 8 | 19.85 | 12.54 | 7 | 16.15 | 11.36 | 8 | 27.45 | 12.96 | (2, 22) | 1.65 | ns | |||
| Scotopic single flash 0.03 | |||||||||||||||
| a-wave | 8 | −3.74 | 3.38 | 6 | −7.00 | 4.97 | 8 | −4.93 | 7.60 | (2, 21) | 0.57 | ns | |||
| b-wave | 8 | 26.07 | 15.84 | 7 | 29.96 | 20.41 | 8 | 69.94 | 43.92 | (2, 22) | 5.23 | 0.0149* | |||
| Scotopic single flash 0.3 | |||||||||||||||
| a-wave | 8 | −6.71 | 8.33 | 5 | −11.44 | 7.44 | 8 | −6.48 | 6.09 | (2, 20) | 0.83 | ns | |||
| b-wave | 8 | 16.40 | 6.57 | 7 | 58.48 | 22.04 | 8 | 103.18 | 48.18 | (2, 22) | 15.48 | <0.0001*** | |||
| Scotopic single flash 3.0 | |||||||||||||||
| a-wave | 7 | −12.39 | 7.73 | 7 | −15.77 | 14.38 | 8 | −14.58 | 12.47 | (2, 21) | 0.16 | ns | |||
| b-wave | 8 | 36.09 | 22.94 | 7 | 86.26 | 36.73 | 8 | 173.09 | 71.07 | (2, 22) | 16.27 | <0.0001*** | |||
| Scotopic single flash 30 | |||||||||||||||
| a-wave | 8 | −11.31 | 7.71 | 5 | −14.82 | 10.16 | 8 | −29.85 | 14.08 | (2, 20) | 6.10 | 0.0095** | |||
| b-wave | 8 | 57.36 | 38.05 | 7 | 81.35 | 55.78 | 8 | 220.80 | 83.16 | (2, 22) | 15.94 | <0.0001*** | |||
| Photopic single flash 3.0 | |||||||||||||||
| a-wave | 7 | −2.54 | 3.96 | 6 | −6.39 | 7.91 | 8 | −5.16 | 5.27 | (2, 20) | 0.77 | ns | |||
| b-wave | 7 | 26.38 | 10.32 | 7 | 38.34 | 20.45 | 8 | 81.67 | 29.12 | (2, 21) | 13.46 | 0.0002*** | |||
| Scotopic 5-Hz flicker | 4 | 93.37 | 11.73 | 8 | 6.02 | 0.94 | 14 | 6.45 | 4.75 | 8 | 7.20 | 2.00 | (3, 30) | 359.87 | <0.0001*** |
| Photopic 10-Hz flicker | 4 | 36.82 | 10.14 | 7 | 11.01 | 7.28 | 11 | 15.68 | 9.48 | 8 | 43.33 | 12.59 | (3, 29) | 18.33 | <0.0001*** |
Comparison of LP-CN03 effects on ERG amplitudes at P30 in WT and rd10 mice, not treated (NT), treated with empty liposome (LP), or LP-CN03, respectively. ns: P > 0.05, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.