Table 3.
ERG amplitude | Pair | Least significant mean difference | CI, μV | P | ||
Mean, μV | SD, μV | |||||
Scotopic single flash 0.03 | ||||||
b-wave | rd10 + LP-CN03 | rd10 NT | 43.87 | 14.90 | [6.18, 81.56] | 0.0209* |
rd10 + LP-CN03 | rd10 + LP | 39.98 | 15.42 | [0.96, 78.99] | 0.0440* | |
rd10 + LP | rd10 NT | 3.89 | 15.42 | [−35.12, 42.91] | ns | |
Scotopic single flash 0.3 | ||||||
b-wave | rd10 + LP-CN03 | rd10 NT | 86.78 | 15.60 | [47.32, 126.24] | <0.0001*** |
rd10 + LP-CN03 | rd10 + LP | 44.70 | 16.15 | [3.86, 85.55] | 0.0305* | |
rd10 + LP | rd10 NT | 42.07 | 16.15 | [1.23, 82.92] | 0.0428* | |
Scotopic single flash 3.0 | ||||||
b-wave | rd10 + LP-CN03 | rd10 NT | 137.00 | 24.27 | [75.59, 198.41] | <0.0001*** |
rd10 + LP-CN03 | rd10 + LP | 86.83 | 25.13 | [23.26, 150.39] | 0.0067** | |
rd10 + LP | rd10 NT | 50.17 | 25.13 | [−13.39, 113.74] | ns | |
Scotopic single flash 30 | ||||||
a-wave | rd10 NT | rd10 + LP-CN03 | 18.54 | 5.55 | [4.38, 32.70] | 0.0097** |
rd10 + LP | rd10 + LP-CN03 | 15.03 | 6.33 | [−1.11, 31.18] | ns | |
rd10 NT | rd10 + LP | 3.51 | 6.33 | [−12.64, 19.65] | ns | |
b-wave | rd10 + LP-CN03 | rd10 NT | 163.44 | 31.07 | [84.85, 242.04] | 0.0001*** |
rd10 + LP-CN03 | rd10 + LP | 139.45 | 32.16 | [58.10, 220.81] | 0.0009** | |
rd10 + LP | rd10 NT | 23.99 | 32.16 | [−57.36, 105.35] | ns | |
Scotopic 5-Hz flicker | WT | rd10 NT | 87.35 | 3.04 | [79.08, 95.62] | <0.0001*** |
WT | rd10 + LP | 86.92 | 2.82 | [79.27, 94.58] | <0.0001*** | |
WT | rd10 + LP-CN03 | 86.17 | 3.04 | [77.91, 94.44] | <0.0001*** | |
rd10 + LP-CN03 | rd10 NT | 1.18 | 2.48 | [−5.57, 7.93] | ns | |
rd10 + LP-CN03 | rd10 + LP | 0.75 | 2.20 | [−5.24, 6.73] | ns | |
rd10 + LP | rd10 NT | 0.43 | 2.20 | [−5.55, 6.41] | ns | |
Photopic 10-Hz flicker | rd10 + LP-CN03 | rd10 NT | 32.32 | 5.21 | [18.03, 46.61] | <0.0001*** |
rd10 + LP-CN03 | rd10 + LP | 27.65 | 4.68 | [14.82, 40.49] | <0.0001*** | |
WT | rd10 NT | 25.81 | 6.31 | [8.50, 43.12] | 0.0020** | |
WT | rd10 + LP | 21.15 | 5.88 | [5.02, 37.27] | 0.0068** | |
rd10 + LP-CN03 | WT | 6.51 | 6.16 | [−10.40, 23.42] | ns | |
rd10 + LP | rd10 NT | 4.67 | 4.87 | [−8.69, 18.02] | ns |
ns: P > 0.05, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001; LP, empty liposome; NT, not treated.