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. 2018 Mar 12;115(13):E2997–E3006. doi: 10.1073/pnas.1718792115

Table 3.

Post hoc analysis using Tukey’s honestly significant difference test on all possible pairwise contrasts for each stimulus condition

ERG amplitude Pair Least significant mean difference CI, μV P
Mean, μV SD, μV
Scotopic single flash 0.03
 b-wave rd10 + LP-CN03 rd10 NT 43.87 14.90 [6.18, 81.56] 0.0209*
rd10 + LP-CN03 rd10 + LP 39.98 15.42 [0.96, 78.99] 0.0440*
rd10 + LP rd10 NT 3.89 15.42 [−35.12, 42.91] ns
Scotopic single flash 0.3
 b-wave rd10 + LP-CN03 rd10 NT 86.78 15.60 [47.32, 126.24] <0.0001***
rd10 + LP-CN03 rd10 + LP 44.70 16.15 [3.86, 85.55] 0.0305*
rd10 + LP rd10 NT 42.07 16.15 [1.23, 82.92] 0.0428*
Scotopic single flash 3.0
 b-wave rd10 + LP-CN03 rd10 NT 137.00 24.27 [75.59, 198.41] <0.0001***
rd10 + LP-CN03 rd10 + LP 86.83 25.13 [23.26, 150.39] 0.0067**
rd10 + LP rd10 NT 50.17 25.13 [−13.39, 113.74] ns
Scotopic single flash 30
 a-wave rd10 NT rd10 + LP-CN03 18.54 5.55 [4.38, 32.70] 0.0097**
rd10 + LP rd10 + LP-CN03 15.03 6.33 [−1.11, 31.18] ns
rd10 NT rd10 + LP 3.51 6.33 [−12.64, 19.65] ns
 b-wave rd10 + LP-CN03 rd10 NT 163.44 31.07 [84.85, 242.04] 0.0001***
rd10 + LP-CN03 rd10 + LP 139.45 32.16 [58.10, 220.81] 0.0009**
rd10 + LP rd10 NT 23.99 32.16 [−57.36, 105.35] ns
Scotopic 5-Hz flicker WT rd10 NT 87.35 3.04 [79.08, 95.62] <0.0001***
WT rd10 + LP 86.92 2.82 [79.27, 94.58] <0.0001***
WT rd10 + LP-CN03 86.17 3.04 [77.91, 94.44] <0.0001***
rd10 + LP-CN03 rd10 NT 1.18 2.48 [−5.57, 7.93] ns
rd10 + LP-CN03 rd10 + LP 0.75 2.20 [−5.24, 6.73] ns
rd10 + LP rd10 NT 0.43 2.20 [−5.55, 6.41] ns
Photopic 10-Hz flicker rd10 + LP-CN03 rd10 NT 32.32 5.21 [18.03, 46.61] <0.0001***
rd10 + LP-CN03 rd10 + LP 27.65 4.68 [14.82, 40.49] <0.0001***
WT rd10 NT 25.81 6.31 [8.50, 43.12] 0.0020**
WT rd10 + LP 21.15 5.88 [5.02, 37.27] 0.0068**
rd10 + LP-CN03 WT 6.51 6.16 [−10.40, 23.42] ns
rd10 + LP rd10 NT 4.67 4.87 [−8.69, 18.02] ns

ns: P > 0.05, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001; LP, empty liposome; NT, not treated.