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. 2018 Apr 2;18:155. doi: 10.1186/s12879-018-3055-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The results of trial sequential analysis under two posaconazole TDM targets. a Trial sequential analysis in 20 trials for posaconazole concentration target of 0.5 mg/L. The required information size (RIS, i.e., number of participates) was calculated as 455. The Z curve crossed the conventional boundary of benefit and the vertical line of RIS. b Trial sequential analysis in 15 trials for posaconazole concentration target of 0.7 mg/L. The RIS was calculated as 693. The Z curve crossed the futility boundary and the vertical line of RIS