Table 3.
Sensitivity analysis: Unadjusted and Adjusted Results for any Non-Targeted Infectious Disease Hospitalizations, excluding vaccine preventable diseases between 16 and 24 months
| Time-dependent vaccination status: Most recent vaccination |
Children No.a |
Events | Person-Years | Unadjusted Infectious Disease Admissions per 100,000 |
Adjusted* Hazard Ratio (95% CI) |
p-value |
|---|---|---|---|---|---|---|
| Overall | 311,519 | 2,651 | 199,827 | 1,327 | ||
| Inactivated | 244,458 | 1,717 | 137,129 | 1,252 | ref | |
| Live | 15,886 | 219 | 15,994 | 1,369 | 0.48 (0.41, 0.55) | <0.0001 |
| Concurrent administration of live and inactivated | 51,175 | 715 | 46,703 | 1,531 | ref | |
| Live | 15,886 | 219 | 15,994 | 1,369 | 0.74 (0.63, 0.86) | 0.0001 |
| Inactivated | 244,458 | 1,717 | 137,129 | 1,252 | ref | |
| Concurrent administration of live and inactivated | 51,175 | 715 | 46,703 | 1,531 | 0.64 (0.59, 0.71) | <0.0001 |
| Sex Specific: | ||||||
| Boys: | 159,806 | 1,459 | 102,416 | 1,425 | ||
| Inactivated | 125,014 | 931 | 70,193 | 1,326 | ref | |
| Live | 8,318 | 122 | 8,267 | 1,476 | 0.48 (0.39, 0.59) | <0.0001 |
| Concurrent administration of live and inactivated | 26,474 | 406 | 23,955 | 1,695 | ref | |
| Live | 8,318 | 122 | 8,267 | 1,476 | 0.71 (0.58, 0.88) | 0.0015 |
| Inactivated | 125,014 | 931 | 70,193 | 1,326 | ref | |
| Concurrent administration of live and inactivated | 26,474 | 406 | 23,955 | 1,695 | 0.67 (0.59, 0.77) | <0.0001 |
| Girls: | 151,713 | 1,192 | 97411 | 1,224 | ||
| Inactivated | 119,444 | 786 | 66935 | 1,174 | ref | |
| Live | 7,568 | 97 | 7727 | 1,255 | 0.48 (0.38, 0.60) | <0.0001 |
| Concurrent administration of live and inactivated | 24,701 | 309 | 22749 | 1,358 | ref | |
| Live | 7,568 | 97 | 7727 | 1,255 | 0.76 (0.60, 0.97) | 0.0247 |
| Inactivated | 119,444 | 786 | 66935 | 1,174 | ref | |
| Concurrent administration of live and inactivated | 24,701 | 309 | 22749 | 1,358 | 0.63 (0.54, 0.72) | <0.0001 |
Number of children by vaccine type at the end of the study
Live vaccines include: MMR, V, and MMRV
Inactivated vaccines include: DTaP, IPV, Hib, HBV, HAV, and MCV (and combined vaccines with these antigens)
See Supplementary table for infections included
Adjusted for chronic conditions, sex, low birth weight, premature, number of hospitalizations prior to 16 months, number of outpatient visits prior to age 16 months, region, urban/rural, birthdate and mother’s age; all HR are stratified by birthdate to control for age, seasonality and year, and interactions between time with number of hospitalizations prior to 16 months, chronic conditions, and number of outpatient visits prior to age 16 months were included to account for the violations of the proportional hazards assumption