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. 2018 Apr 2;19:227. doi: 10.1186/s12864-018-4600-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — a Expression profiles of genes known to be differentially expressed in early and late procyclic forms. GPEET (Tb927.6.510) is the major surface protein of early procyclic forms [4]. HK1: hexokinase 1; HK2: hexokinase 2; AC320, adenylate cyclase (Tb927.5.320); AC330, adenylate cyclase (Tb927.5.330); calflagins (Tb927.8.5440, 5460, 5465 and 5470); PTT, putative pteridine transporter. Reads for HK1 and HK2 were restricted to the 3’ UTRs. b Down-regulation of glycosomal enzymes in stumpy forms. Tb927.1.3830, glucose-6-phosphate isomerase; Tb927.10.5620, aldolase; Tb927.3.3270, phosphofructokinase; Tb927.6.4280, GAPDH; Tb927.8.3530, glycerol-3-phosphate dehydrogenase; Tb927.9.12550, glycerol kinase 1. Sl: slender bloodstream forms; St: stumpy bloodstream forms; Ea: early procyclic forms; La: late procyclic forms. RPM: reads per million