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. 2018 Feb;13(2):244–251. doi: 10.4103/1673-5374.226395

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Effect of vagus nerve stimulation on orexin-A expression in the prefrontal cortex of rats in a TBI-induced coma (enzyme-linked immunosorbent assay).

Data are expressed as the mean ± SD (n = 6 per group; one-way analysis of variance followed by Tukey's test); *P < 0.05, vs. control group and stimulated group; #P < 0.05, vs. antagonist group; †P < 0.05, vs. 6 hours after TBI. Control group: Healthy rats with sham operation and anesthesia. TBI group: Free-fall drop was used to establish the model of TBI-induced coma. Stimulated group: TBI-induced comatose rats subjected to vagus nerve stimulation. Antagonist group: Comatose rats received intracerebroventricular injection of the orexin receptor type 1 antagonist SB334867 and vagus nerve stimulation. TBI: Traumatic brain injury.