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. 2018 Feb;13(2):244–251. doi: 10.4103/1673-5374.226395

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Effect of vagus nerve stimulation on OX1R expression in the prefrontal cortex of rats with TBI-induced coma (immunostaining, light microscope, original magnification, 400×).

Increased OX1R expression was detected within the cytoplasm of neurons in the prefrontal cortex at 12 h after TBI. Control group: Healthy rats with sham operation and anesthesia. TBI group: TBI-induced coma. Stimulated group: Rats in a TBI-induced coma subjected to vagus nerve stimulation. Antagonist group: Comatose rats received intracerebroventricular injection of the OX1R antagonist SB334867 and vagus nerve stimulation. TBI: Traumatic brain injury; OX1R: orexin receptor type 1; h: hours.