. 2018 Feb 28;14(2):80–85. doi: 10.6026/97320630014080

Table 1. Targeting cellular metabolism improves cancer therapeutics.

Targeted metabolism	Targeted metabolic enzymes	Metabolic inhibitors	Cancer therapeutics	Cancer types (in vitro / in vivo)	Reference
Glycolysis	GLUT1	Phloretin	Daunorubicin	Colon cancer (in vitro), Leukemia (in vitro)	[33]
	GLUT4	Ritonavir	Doxorubicin	Multiple myeloma (in vitro)	[34]
	HK	3-BrPA	Prednisolone	Leukemia (in vitro)	[35]
Citric acid cycle	PDK3	siRNA	Patlitaxel	Cervical Cancer	[36]
Citric acid cycle	PDK	DCA	Omeprazole	Fibrosarcoma (in vitro and in vivo)	[37]
Fatty acid synthesis	FASN	Cerulenin	Docetaxel	Breast cancer (in vitro)	[38]
Fatty acid synthesis	FASN	Orlistat	Adriamycin	Breast cancer (in vitro)	[39]