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. 2018 Mar 26;11:92. doi: 10.3389/fnmol.2018.00092

Figure 1.

Figure 1

The effects of TMZ and EMAP-II on U87-GSCs and U251-GSCs viability, migration and invasion. (A) Cytotoxic effects of the combination of EMAP-II and TMZ on U87-GSCs and U251-GSCs compared with the control treatment and EMAP-II and TMZ alone. The combination of EMAP-II and TMZ significantly inhibited cell viability of U87-GSCs and U251-GSCs compared with the control treatment and EMAP-II and TMZ alone. Data are presented as the mean ± SD from three independent experiments. (B) GSC cell migration and invasion were investigated by transwell assays after treatment with EMAP-II and TMZ. Compared with the control treatment and EMAP-II and TMZ alone, the migration and invasion of GSC are inhibited in the combination of EMAP-II and TMZ group. Data are presented as the mean ± SD of n = 3. *P < 0.05, **P < 0.01 vs. control group, #P < 0.05, ##P < 0.01 vs. TMZ group, &P < 0.05, &&P < 0.01 vs. EMAP-II group. Scale bars represent 40 μm.