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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Thromb Haemost. 2018 Feb 16;118(3):502–513. doi: 10.1055/s-0038-1627453

Fig. 5.

Fig. 5

TFPI-α inhibition normalizes platelet-dependent fibrin formation in haemophiliac blood. Platelet thrombi were generated by blood perfusion over microspots of collagen with indicated concentrations of TF; blood samples were treated with vehicle or anti-TFPI antibodies. Time to first fibrin formation was recorded per microspot during blood perfusion at 150 s−1. Presented are times to fibrin formation. (A) Blood from control subjects. (B, C) Blood from haemophilia A patients A1 (2% factor VIII) and A2 (<1% with 3.8 BU factor VIII inhibitor). (D, E) Blood from haemophilia B patients B1 (5% factor IX) and B2 (7% factor IX). Means ± SEM, n = 3–4; *p < 0.05 versus vehicle.