Table 3.

Enrichment results for gene ontology (GO) analysis of differentially-methylated regions between selection lines across and within sexes

GO ID	GO term
Across sexes
GO:0005261	Cation channel activity
GO:0003723	RNA binding
GO:0003924	GTPase activity
GO:0005759	Mitochondrial matrix
GO:0006412	Translation
GO:0006816	Calcium ion transport
GO:0042254	Ribosome biogenesis
GO:0042391	Regulation of membrane potential
Female
GO:0044456	Synapse part
GO:0043197	Dendric spine
GO:0098878	Neurotransmitter complex
GO:0022803	Passive transmembrane transporter activity
GO: 0016597	Amino acid binding
GO:0008066	Glutamate receptor activity
Male
GO:1902710	GABA receptor complex
GO:0045211	Postsynaptic membrane
GO:0005657	Replication fork
GO:0034776	Response to histamine
GO:0006312	Mitotic recombination
GO:0004520	Endodeoxyribonuclease activity
GO:0005254	Chloride channel activity
GO:0008094	DNA-dependent ATPase activity

Annotations for differentially-methylated windows were used to search for enrichment of terms in the groups, both for overall effects of selection objective and sex-specific changes