Fig. 4.

Functional annotation of significantly altered proteins. (A) Venn diagram of total 541 proteins significantly altered in three treatment groups (single-agent and combined drugs) at four time points. Among them, 289 proteins were uniquely altered by combined birinapant/paclitaxel. (B) Bar chart of the top eight mostly enriched biological processes represented by 541 altered proteins in response to drug treatment. These processes included oxidation-reduction, regulation of apoptosis, protein transport, regulation of proliferation, cell cycle, lipid biosynthetic processes, immune response, and cytoskeleton organization. The p value (-log10) of each biological process is shown.