| Mitochondrial Function and Metabolism |
|
|
|
| Mitochondrial dysfunction |
AIFM1, APP, ATP5A1, ATP5B, ATP5H, ATP5O, COX7A2, COX7A2L, CYB5A, FIS1, NDUFA11, NDUFB4, NDUFB6, PRDX3, SOD2, TXN2, TXNRD2, UQCRC1, UQCRFS1, VDAC1, VDAC2, VDAC3 |
6.57 |
37 |
| Oxidative phosphorylation |
ATP5H, ATP5O, ATP5A1, ATP5B, ATP6VOD1, ATP6V0A1, NDUFA11, NDUFB6, TCIRG1, COX7A2, COX7A2L, AIFM1, NSDHL, PMVK, EBP, IDI1, MVK, UQCRC1, UQCRFS1, NDUFB4 |
3.28 |
|
| Citrate cycle (TCA cycle) |
MDH2, PCK2 |
1.43 |
|
| Glycolysis/gluconeogenesis |
GALM, HK1, LDHB, PCK2, PGM2 |
1.38 |
|
| Pyruvate metabolism |
LDHB, MDH2, ME2, PCK2 |
1.19 |
|
| Fatty acid metabolism |
ACADS, ECHS1, ACAA2 |
2.03 |
|
| Fatty acid elongation in mitochondria |
ECHS1, ACAA2 |
1.17 |
|
| Fatty acid beta-oxidation |
ACAA2, ECHS1, HSD17B4, SLC27A4, ACADS, HSD17B4 |
2.21 |
|
| Superpathway of cholesterol biosynthesis |
EBP, IDI1, MVK, NSDHL, PMVK, SQLE |
1.85 |
|
| Cell Growth and Apoptosis |
|
|
|
| Apoptosis signaling pathway |
AIFM1, CHP1, RIPK1, AKT1, AKT2 |
2.68 |
29 |
| MAPK signaling pathway |
LAMTOR3, CHP1, NFKB2, RRAS2, RPS6KA4, STK4, AKT1, AKT2, CRKL |
3.26 |
|
| ERBB signaling pathway |
CAMK2D, ABL2, AKT1, AKT2, CRKL |
3.36 |
|
| mTOR signaling pathway |
AKT1, AKT2, FAU, PIK3C2A, RHOG, RPS2, RPS9, RPS13, RPS15, RPS18, RPS23, RPS26, RPS29, RPS6KA4, RPTOR, RRAS2 |
1.62 |
|
| Insulin receptor signaling |
AKT1, AKT2, CRKL, EIF2B2, PIK3C2A, RPTOR, RRAS2, STX4, SYNJ2 |
1.26 |
|
| PI3K/AKT signaling pathway |
AKT1, AKT2, CRKL, NFKB2, PIK3C2A |
2.02 |
|
| JAK/STAT signaling pathway |
AKT1, AKT2, NFKB2, PIK3C2A, RRAS2 |
2.11 |
|
| Insulin signaling pathway |
HK1, PCK2, PHKA1, RPTOR, AKT1, AKT2, CRKL |
4.71 |
|
| Cell Cycle |
| G2/M DNA damage checkpoint regulation |
AURKA, PKMYT1, CKS1B, AJUBA, ZC3HC1 |
1.85 |
21 |
| Mitosis |
F2, DBI, APOE, CKAP2, GRN, AJUBA, KIFC1, ZC3HC1, AURKA, CDCA8, TAF6, ARRB1, AKT1, ERRFI1, UBE2C, NUDCD3, CUL7, AXL, BUB1B, PKMYT1, PPP1R12C |
1.43 |
|
| Ploidy |
SQSTM1, CKAP2, AURKA, AKT1, CKSlB, BUB1B |
1.32 |
|
