Table II. Phosphorylation sites responsive to only one MKK1/2 or ERK1/2 inhibitor.

Uniprot ID	Gene name	Protein name	Position	TRA/DMSOa	SEL/DMSOa	SCH/DMSOa	GDC/DMSOa
Q86UE4	MTDH	Protein LYRIC	S298	−1.004	−0.066	−0.019	0.250
Q15154	PCM1	Pericentriolar material 1 protein	S93	−0.88	−0.01	0.19	0.58
P10071	GLI3	Transcriptional activator/repressor	S445	−0.17	−2.07	−0.18	−0.23
P38159	RBMX	RNA-binding motif protein, X chr.	S88	−0.061	−0.112	−0.952	−0.096
Q04637	EIF4G1	Eukaryotic translation initiat. factor 4 γ1	S1209	0.335	0.215	−0.146	−2.659
Q16555	DPYSL2	Dihydropyrimidinase-related prot. 2	T509	0.234	0.229	0.046	−1.561
Q14195	DPYSL3	Dihydropyrimidinase-related prot. 3	T509	0.33	0.243	0.097	−1.370
Q03252	LMNB2	Lamin-B2	S17	−0.26	0.03	−0.28	−1.41
Q13098	GPS1	COP9 signalosome subunit 1	T479	−0.026	0.173	0.064	−1.277
Q68DQ2	CRYBG3	Very large A-kinase anchor protein	T2902	−0.055	0.115	0.108	−1.275
Q659C4	LARP1B	La-related protein 1B	S900	0.098	0.161	0.186	−1.077
Q9H840	GEMIN7	Gem-associated protein 7	T3	0.295	0.229	0.272	−1.015
O14777	NDC80	Kinetochore prot. NDC80 homolog	S69	−0.134	0.319	0.115	−0.902
Q6Y7W6	GIGYF2	PERQ aa-rich with GYF protein 2	S189	−0.051	0.183	−0.107	−0.902
P08034	GJB1	Gap junction beta-1 protein	S266	−0.043	−0.079	−0.065	−0.872
Q8NCF5	NFATC2IP	NFATC2-interacting protein	S84	0.357	0.249	0.081	−0.865
Q8NDD1	C1orf131	Uncharacterized protein C1orf131	S280	−0.026	0.161	−0.019	−0.850
Q9UHR4	BAIAP2L1	Brain angiogenesis inhibitor 1–2-like 1	S261	−0.104	−0.451	−0.063	0.883b
Q8WUZ0	BCL7C	B-cell CLL/lymphoma 7 family mem. C	S126	−0.425	−0.595	−0.126	0.898b
Q09666	AHNAK	Neuroblast differentiation assoc. prot	T4564	−0.211	0.252	−0.453	0.995b
P19532	TFE3	Transcription factor E3	S548	−0.194	−0.045	0.104	1.045b

^a Empirical Bayes-generated log₂(combined ratio) (n ≥ 2) of SILAC replicates for each experiment.

^b Four phosphosites were significantly increased in response to only one inhibitor.