Table II. Network characteristics at 90 days of gestation.
Five subnetworks (communities) were obtained at 90 days of gestation. aNodes with high betweenness. bThe phenotype correlations with MyHC embryonic (Emb.), adult fast and muscle glycogen content were analyzed using spatial statistics tools. cAdditional File 10 shows all significantly enriched GO terms for each sub-network. *Significantly high (P < 0.05) betweenness using a permutation test.
| 90 days of gestation | |||||
|---|---|---|---|---|---|
| Community | Nb. of nodes | Nb. of edges | Important nodea | Phenotype correlationb | Gene Ontologyc |
| 1 | 18 | 26 | FETUB | Glycogen & Emb. MyHC | glycolysis, myofibril, mitochondrion |
| 2 | 19 | 55 | PSMC5 (Iso 2)* | Glycogen & Fast MyHC | gluconeogenesis, actin filaments, mitochondrion |
| 3 | 21 | 47 | PDIA3 (Iso 1) | - | respiratory electron transport chain, cell redox homeostasis, mitochondrion |
| 4 | 20 | 49 | TNNT3 (Iso 2)* | Emb. MyHC | gluconeogenesis, muscle filament sliding and development, cell cycle checkpoint |
| 5 | 16 | 33 | ANXA2 (Iso 2) | - | creatine metabolic process, sarcolemma |