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Copper-only SODs can react with superoxide from both the host and fungal pathogen. Shown is a model depicting a fungal copper-only SOD at the host–pathogen interface where it can react with superoxide from host NOX (macrophages or neutrophils) or from fungal NOX. The H2O2 generated may be used in signaling as has been shown for C. albicans where copper-only SOD5 and the FRE8 NOX promote morphogenesis of the fungus (78).
