Figure 1.
Representation of the domain organization of integrin αIIbβ3. On the left, the open conformation is depicted as a schematic with the α subunit divided into four different domains and the β subunit divided into eight domains. Each domain is colored and labeled. The knees of the protein are highlighted by red dashed lines and lie between the thigh and calf-1 domains and between the PSI and EGF-1/EGF-2 domains of the α and β subunits, respectively. On the right, the αIIbβ3 ectodomain starting structure (Protein Data Bank code 3FCS) in the bent conformation is depicted in surface representation (right) with domains colored as on the left.