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A, schematic representation of the Syk kinase structure. The N-SH2 and C-SH2 are the regulatory domains that are connected to each other through IA; they are named tandem SH2 (tSH2) together. tSH2 are connected to kinase domain via IB. Tyrosines 348 and 352 get phosphorylated during protein activation and in this study were mutated to phenylalanine. B, SDS-PAGE of purified proteins. For each protein preparation 5 μg of protein was loaded on the gel.
