Table 1.
Reports on fate mapping during fibrosis
| Report | Fate mapping system | Model | EMT | |
|---|---|---|---|---|
| Lung fibrosis | ||||
| Kim et al. 2006 | Sftpc-rtTA/tetO-Cre/RosaLacZ | AdTGF-β | Yes | |
| Kim et al. 2009 | Sftpc-rtTA/tetO-Cre/ZEG | Bleo | Yes | |
| Tanjore et al. 2009 | Sftpc-Cre/RosaLacZ | Bleo | Yes | |
| Hashimoto et al. 2010 | Tek-Cre/RosaLacZ | Bleo | Yes | |
| DeMaio et al. 2012 | Nkx2-1-Cre/RosaLacZ | Bleo | Yes | |
| Rock et al. 2011 | Sftpc-CreER/dTomato | Bleo | No | |
| Balli et al. 2013 | Sftpc-rtTA/tetO-Cre/RosaLacZ | XRT | Yes | |
| Kidney fibrosis | ||||
| Iwano et al. 2002 | Ggt1-Cre/RosaLacZ | UUO | Yes | |
| Zeisberg et al. 2008 | Tek-Cre/RosaYFP | UUO | Yes | |
| Humphreys et al. 2010 | Six2-Cre/RosaLacZ | UUO | No | |
| LeBleu et al. 2013 | Ggt1-Cre/RosaLacZ | UUO | Yes | |
| Cdh5-Cre/RosaYFP | UUO | Yes | ||
| Gastrointestinal and liver fibrosis | ||||
| Zeisberg et al. 2007b | Alb-Cre/RosaLacZ | CCl4 | Yes | |
| Flier et al. 2010 | Vil1-Cre/RosaLacZ | TNBS | Yes | |
| Taura et al. 2010 | Alb-Cre/RosaLacZ | CCl4 | No | |
| Chu et al. 2011 | Alb-Afp-Cre/RosaYFP | CCl4 | No | |
| Cardiac infarct | ||||
| Zhou and Pu 2011 | Wt1-CreER/tmGFP | Art ligation | Yes | |
| Zeisberg et al. 2007a | Tie1-Cre/Rosa26 | Ao banding | Yes | |
| Pericyte→Myofib | ||||
| Lung fibrosis | ||||
| Rock et al. 2011 | Cspg4-CreER/fGFP | Bleo | No | |
| Hung et al. 2013 | Foxd1-Cre/dTomato | Bleo | Yes | |
| Kidney fibrosis | ||||
| Humphreys et al. 2010 | Foxd1-Cre/Rosa26 | UUO | Yes | |
| LeBleu et al. 2013 | Cspg4-Cre/RosaYFP | UUO | No | |
| Pdgfrb-Cre/RosaYFP | UUO | No | ||
| BM→Myofib | ||||
| Lung fibrosis | ||||
| Hashimoto et al. 2004 | GFP BMT | Bleo | No | |
| Schmidt et al. 2003 | ex vivo labeling | OVA | Yes | |
| Madala et al. 2014 | GFP BMT | TGF-α | No | |
| Kidney Fibrosis | ||||
| Iwano et al. 2002 | S100a4-GFP BMT | UUO | Yes | |
| LeBleu et al. 2013 | Acta2-RFP BMT | UUO | Yes | |
| Liver fibrosis | ||||
| Higashiyama et al. 2009 | Col1a2-GFP BMT | CCl4 | No | |
| Kisseleva et al. 2006 | Col1a1-GFP BMT | BDL | No | |
EMT, epithelial–mesenchymal transition; AdTGF-β, adenovirus encoding active TGF-β1; bleo, bleomycin; XRT, X-ray treatment; OVA, ovalbumin; UUO, unilateral ureteral obstruction; TNBS, trinitrobenzene sulfonic acid; Pericyte→myofib, pericyte to myofibroblast transition; BM→myofib, bone marrow–derived cell to myofibroblast transition; art, arterial; Ao, aortic; BMT, bone marrow transplant; CCl4, carbon tetrachloride; BDL, bile duct ligation; GFP, green fluorescent protein.