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. 2018 Mar 29;13:1927–1944. doi: 10.2147/IJN.S153107

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© 2018 Lu et al. This work is published and licensed by Dove Medical Press Limited

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Illustration of CD44-LP for active CD44-targeting TAIII delivery and enhancing antitumor activity against CD44-overexpressing HepG2 cells.

Note: Anti-CD44 antibody was conjugated to LP through the reaction of sulfhydryl residues on the antibodies with the C-terminal maleimide groups of the PEG chains.

Abbreviations: DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(PEG)-2000]; DSPE-PEG2000-Mal, DSPE-PEG2000-maleimide; LP, liposomes; TAIII, timosaponin AIII; PEG, polyethylene glycol.