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. 2018 Mar 29;13:1927–1944. doi: 10.2147/IJN.S153107

Table 2.

Main pharmacokinetic parameters of TAIII in male Sprague-Dawley rats (n=5)

Parameters TAIII LP CD44-LP
AUC [(mg/L)×h] 9.08±1.65 15.22±3.95** 17.52±6.40**
MRT0–t (h) 3.25±0.22 20.22±2.10** 20.84±4.43**
t1/2z (h) 2.32±0.38 32.96±17.15** 24.94±9.07**
CLz (L/h/kg) 1.13±0.21 0.54±0.07** 0.57±0.21**
Vz (L/kg) 3.82±1.06 26.02±14.99** 20.93±12.59**
Cmax (mg/L) 3.69±0.58 5.46±1.08** 5.48±1.39**

Notes:

**

P<0.01, compared to free TAIII. Data are presented as mean ± standard deviation.

Abbreviations: AUC, area under the curve; LP, liposomes; MRT, mean residence time; TAIII, timosaponin AIII.