Table 2.

Main pharmacokinetic parameters of TAIII in male Sprague-Dawley rats (n=5)

Parameters	TAIII	LP	CD44-LP
AUC [(mg/L)×h]	9.08±1.65	15.22±3.95**	17.52±6.40**
MRT0–t (h)	3.25±0.22	20.22±2.10**	20.84±4.43**
t1/2z (h)	2.32±0.38	32.96±17.15**	24.94±9.07**
CLz (L/h/kg)	1.13±0.21	0.54±0.07**	0.57±0.21**
Vz (L/kg)	3.82±1.06	26.02±14.99**	20.93±12.59**
Cmax (mg/L)	3.69±0.58	5.46±1.08**	5.48±1.39**

Notes:

^**P<0.01, compared to free TAIII. Data are presented as mean ± standard deviation.

Abbreviations: AUC, area under the curve; LP, liposomes; MRT, mean residence time; TAIII, timosaponin AIII.